Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling
نویسندگان
چکیده
منابع مشابه
Stem cell quiescence.
Adult stem cells are maintained in a quiescent state but are able to exit quiescence and rapidly expand and differentiate in response to stress. The quiescent state appears to be necessary for preserving the self-renewal of stem cells and is a critical factor in the resistance of cancer stem cells (CSCs) to chemotherapy and targeted therapies. Limited knowledge about quiescence mechanisms has p...
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Adult stem cells are maintained in a quiescent state but are able to exit quiescence and rapidly expand and differentiate in response to stress. The quiescent state appears to be necessary for preserving the selfrenewal of stem cells and is a critical factor in the resistance of cancer stem cells (CSCs) to chemotherapy and targeted therapies. Limited knowledge about quiescence mechanisms has pr...
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Mammalian epidermis is maintained by self-renewal of stem cells and terminal differentiation of their progeny. New data reveal a diversity amongst stem cells that was previously unrecognized. Different stem cell populations have different locations and differ in whether they are quiescent or actively cycling. During normal epidermal homeostasis, each stem cell population feeds a restricted numb...
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Comment on: Campaner S, et al. Cell Cycle 2013; 12;3663–72; PMID:24091730; http://dx.doi.org/10.4161/cc.26584 Senthil Raja Jayapal and Philipp Kaldis; Institute of Molecular and Cell Biology (IMCB); A*STAR (Agency for Science, Technology and Research); Singapore, Republic of Singapore; National University of Singapore (NUS); Department of Biochemistry; Singapore, Republic of Singapore; *Email: ...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2019
ISSN: 1934-5909
DOI: 10.1016/j.stem.2019.01.001